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William R. Jacobs Jr. : ウィキペディア英語版 | William R. Jacobs Jr.
William R. Jacobs Jr., is a professor of Microbiology and Immunology and Professor of Genetics at Albert Einstein College of Medicine in The Bronx, New York, where he is also a Howard Hughes Medical Institute Investigator. Jacobs is a specialist in the molecular genetics of Mycobacteria.〔Hatfull, Graham F., and William R. Jacobs. Molecular Genetics of Mycobacteria. Washington, D.C.: ASM, 2000. Print.〕 His research efforts are aimed at discovering genes associated with virulence and pathogenicity in ''M. tuberculosis'' and developing attenuated strains for use as vaccines. He is a Founding Scientist at the KwaZulu-Natal Research Institute for Tuberculosis and HIV.〔"Founding Scientists." K-RITH. HHMI/UKZN, 2012. Web. 〕 == Early career ==
In 1985, Jacobs joined Barry Bloom's lab at Albert Einstein College of Medicine as a post-doctoral fellow〔"Barry R. Bloom." Harvard University Distinguished Service Professor. Harvard University, n.d. Web. .〕 to work on the resurgent problem of tuberculosis. In 1987, the two co-authored a ground-breaking〔Vijaya, S. "The Genetics O fMycobacterium Tuberculosis." ''Journal of Genetics'' 77.2-3 (1998): 123-28. Print.〕 paper published in ''Nature'' describing a novel system for the genetic manipulation of mycobacteria, "Introduction of Foreign DNA into Mycobacteria Using a Shuttle Phasmid".〔Jacobs, William R., Margareta Tuckman, and Barry R. Bloom. "Introduction of Foreign DNA into Mycobacteria Using a Shuttle Phasmid." ''Nature'' 327.6122 (1987): 532-35〕 By demonstrating the utility of shuttle phasmids as DNA transporters between ''E. coli'' plasmids and mycobacteriophages, this paved the way for recombinant DNA research for mycobacteria.〔Caldwell, Mark. "Health & Medicine / Infectious Diseases." Resurrection of a Killer. Discover Magazine, n.d. Web. .〕
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